PDBe 3cok

X-ray diffraction
2.25Å resolution

Crystal structure of PLK4 kinase

Released:
Source organism: Homo sapiens
Entry authors: Atwell S, Burley SK, Houle A, Leon B, Pelletier LA, Sauder JM, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 31.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00444 (Residues: 2-275; Coverage: 28%)
  • Best match: O00444-3 (Residues: 1-234)
Gene names: PLK4, SAK, STK18
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 84.516Å b: 102.151Å c: 63.058Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.261
Expression system: Escherichia coli BL21(DE3)