› 3cnk

X-ray diffraction
1.65Å resolution

Crystal Structure of the dimerization domain of human filamin A

Released:
DOI: 10.2210/pdb3cnk/pdb
PDB entry 3cnk coloured by chain, front view.
PDB entry 3cnk coloured by chain, side view.
PDB entry 3cnk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the dimerization domain of human filamin A.
Seo MD, Seok SH, Im H, Kwon AR, Lee SJ, Kim HR, Cho Y, Park D, Lee BJ
Proteins 75 258-63 (2009)
PMID: 19137608

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filamin-A Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 9.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21333 (Residues: 2559-2647; Coverage: 3%)
Gene names: FLN, FLN1, FLNA
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P21212
Unit cell:
a: 57.845Å b: 94.642Å c: 40.976Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Filamins in mechanosensing and signaling.
Razinia et al. (2012)
1 more

2 mentions without citation

The filamins: organizers of cell structure and function.
Nakamura et al. (2011)
1 more