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Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene

X-ray diffraction
1.52Å resolution
PDB entry 3cn0 coloured by chain, front view.
PDB entry 3cn0 coloured by chain, side view.
PDB entry 3cn0 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Transthyretin
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Multimeric state: homo tetramer
PDBe Complex ID: PDB-CPX-136168
Assembly 2 (preferred)
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Assembly Name: Transthyretin
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Multimeric state: homo dimer
Accessible surface area: 11040.56 Å2
Buried surface area: 1755.51 Å2
Dissociation area: 877.76 Å2
Dissociation energy (ΔGdiss): 5.57 kcal/mol
Dissociation entropy (TΔSdiss): 11.54 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136167

Macromolecules

Transthyretin
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Pfam: HIUase/Transthyretin family
InterPro:
CATH: Transthyretin/hydroxyisourate hydrolase domain
Transthyretin in PDB entry 3cn0, assembly 2, front view.
Transthyretin in PDB entry 3cn0, assembly 2, side view.
Transthyretin in PDB entry 3cn0, assembly 2, top view.
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