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Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

X-ray diffraction
2.84Å resolution
PDB entry 3cld coloured by chain, front view.
PDB entry 3cld coloured by chain, side view.
PDB entry 3cld coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glucocorticoid receptor and Nuclear receptor coactivator 2
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Multimeric state: hetero tetramer
Accessible surface area: 23313.25 Å2
Buried surface area: 3033.54 Å2
Dissociation area: 587.99 Å2
Dissociation energy (ΔGdiss): 1.67 kcal/mol
Dissociation entropy (TΔSdiss): 12.97 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-137451

Macromolecules

Glucocorticoid receptor
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04150 (Residues: 521-777; Coverage: 33%)
Gene names: GRL, NR3C1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Glucocorticoid receptor in PDB entry 3cld, assembly 1, front view.
Glucocorticoid receptor in PDB entry 3cld, assembly 1, side view.
Glucocorticoid receptor in PDB entry 3cld, assembly 1, top view.
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Nuclear receptor coactivator 2
Chains: C, H
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Nuclear receptor coactivator 2 in PDB entry 3cld, assembly 1, front view.
Nuclear receptor coactivator 2 in PDB entry 3cld, assembly 1, side view.
Nuclear receptor coactivator 2 in PDB entry 3cld, assembly 1, top view.
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