PDBe 3cld

X-ray diffraction
2.84Å resolution

Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 2 Chains: C, H
Molecule details ›
Chains: C, H
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Glucocorticoid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04150 (Residues: 521-777; Coverage: 33%)
Gene names: GRL, NR3C1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P61
Unit cell:
a: 127.34Å b: 127.34Å c: 77.772Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.207 0.267
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)