PDBe 3ckz

X-ray diffraction
1.9Å resolution

N1 Neuraminidase H274Y + Zanamivir

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chain: A
Molecule details ›
Chain: A
Length: 385 amino acids
Theoretical weight: 42.21 KDa
Source organism: Influenza A virus (A/Viet Nam/1203/2004(H5N1))
Expression system: Influenza A virus
UniProt:
  • Canonical: Q6DPL2 (Residues: 63-447; Coverage: 86%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P4212
Unit cell:
a: 115.146Å b: 115.146Å c: 64.197Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.228
Expression system: Influenza A virus