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Human GRK2 in Complex with Gbetagamma subunits

Source organisms:
Biochemical function: protein binding
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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EC 2.7.11.15: [Beta-adrenergic-receptor] kinase

Reaction catalysed:
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate
Systematic name:
ATP:[beta-adrenergic-receptor] phosphotransferase
Alternative Name(s):
  • ADRBK1
  • ATP:beta-adrenergic-receptor phosphotransferase
  • Adrenergic receptor kinase
  • BARK1
  • Beta(2)ARK
  • Beta-AR kinase
  • Beta-ARK
  • Beta-ARK 1
  • Beta-ARK 2
  • Beta-ARK1
  • Beta-adrenergic receptor-specific kinase
  • Beta-adrenergic-receptor kinase
  • Beta-adrenergic-receptor kinase (phosphorylating)
  • Beta-adrenoceptor kinase
  • Beta-adrenoceptor kinase 1
  • Beta-adrenoceptor kinase 2
  • Beta-receptor kinase
  • GRK2
  • GRK3
  • STK15
  • [Beta-adrenergic-receptor] kinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
The deposited structure of PDB entry 3cik contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 7 copies in chain B.

PF00631
Domain description: GGL domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
The deposited structure of PDB entry 3cik contains 1 copy of Pfam domain PF00631 (GGL domain) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain C [auth G].

PF00169
Domain description: PH domain
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of Pfam domain PF00169 (PH domain) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.

PF00615
Domain description: Regulator of G protein signaling domain
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of Pfam domain PF00615 (Regulator of G protein signaling domain) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR000239
Domain description: GPCR kinase
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR015898
Domain description: G-protein gamma-like domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001770
Domain description: G-protein, gamma subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001632
Domain description: G-protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR036284
Domain description: G-protein gamma-like domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR000961
Domain description: AGC-kinase, C-terminal
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR016137
Domain description: RGS domain
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR016346
Domain description: Guanine nucleotide-binding protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR044926
Domain description: RGS, subdomain 2
Occurring in:
  1. Beta-adrenergic receptor kinase 1
IPR036305
Domain description: RGS domain superfamily
Occurring in:
  1. Beta-adrenergic receptor kinase 1

Structure domains

CATH CATH domains
1.10.287.1270
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 1.10.287.1270 (Helix Hairpins) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.
4.10.260.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: G Protein Gi Gamma 2
Homology: Transducin (heterotrimeric G protein), gamma chain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 4.10.260.10 (G Protein Gi Gamma 2) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain C [auth G].
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 1 copy in chain B.
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.
1.10.167.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Regulator of G-protein Signalling 4; domain 2
Homology: Regulator of G-protein Signalling 4, domain 2
Occurring in:
  1. Beta-adrenergic receptor kinase 1
The deposited structure of PDB entry 3cik contains 1 copy of CATH domain 1.10.167.10 (Regulator of G-protein Signalling 4; domain 2) in Beta-adrenergic receptor kinase 1. Showing 1 copy in chain A.

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