PDBe 3cc6

X-ray diffraction
1.6Å resolution

Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B)

Released:
Source organism: Homo sapiens
Entry authors: Busam RD, Lehtio L, Karlberg T, Arrowsmith CH, Bountra C, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Helleday T, Herman MD, Johansson A, Johansson I, Kallas A, Kotenyova T, Moche M, Nilsson ME, Nordlund P, Nyman T, Persson C, Sagemark J, Svensson L, Thorsell AG, Tresaugues L, Van den Berg S, Weigelt J, Welin M, Berglund H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 2-beta Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 32.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14289 (Residues: 414-692; Coverage: 28%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 37.45Å b: 96.14Å c: 43.2Å
α: 90° β: 93.66° γ: 90°
R-values:
R R work R free
0.187 0.184 0.219
Expression system: Escherichia coli