PDBe 3cbx

X-ray diffraction
1.7Å resolution

The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide

Released:
Source organism: Homo sapiens
Primary publication:
Inhibition of Wnt signaling by Dishevelled PDZ peptides.
Nat. Chem. Biol. 5 217-9 (2009)
PMID: 19252499

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 105 amino acids
Theoretical weight: 11.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14641 (Residues: 264-354; Coverage: 12%)
Gene name: DVL2
Sequence domains: PDZ domain (Also known as DHR or GLGF)
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 51.214Å b: 61.112Å c: 65.818Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.227
Expression system: Escherichia coli