PDBe 3cbl

X-ray diffraction
1.75Å resolution

Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Synthetic peptide Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 650 Da
Source organism: Synthetic construct
Expression system: Not provided
Tyrosine-protein kinase Fes/Fps Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 42.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07332 (Residues: 448-822; Coverage: 46%)
Gene names: FES, FPS
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 35.679Å b: 77.178Å c: 149.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.18 0.227
Expression systems:
  • Not provided
  • Escherichia coli