PDBe 3c9w

X-ray diffraction
2.5Å resolution

Crystal Structure of ERK-2 with hypothemycin covalently bound

Released:
Source organism: Rattus norvegicus
Primary publication:
Molecular modeling and crystal structure of ERK2-hypothemycin complexes.
J. Struct. Biol. 164 18-23 (2008)
PMID: 18571434

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 357 amino acids
Theoretical weight: 41.2 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63086 (Residues: 2-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 45.815Å b: 117.298Å c: 65.871Å
α: 90° β: 89.82° γ: 90°
R-values:
R R work R free
0.197 0.197 0.274
Expression system: Escherichia coli