› 3c6w

X-ray diffraction
1.75Å resolution

Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptide

Released:
DOI: 10.2210/pdb3c6w/pdb
PDB entry 3c6w coloured by chain, front view.
PDB entry 3c6w coloured by chain, side view.
PDB entry 3c6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.
Champagne KS, Saksouk N, Peña PV, Johnson K, Ullah M, Yang XJ, Côté J, Kutateladze TG
Proteins 72 1371-6 (2008)
PMID: 18623064

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163451 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibitor of growth protein 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 59 amino acids
Theoretical weight: 6.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WYH8 (Residues: 184-236; Coverage: 22%)
Gene name: ING5
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)
H3K4me3 histone peptide Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
1 modified residue:
Ligand M3L 2 x M3L

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P43
Unit cell:
a: 68.14Å b: 68.14Å c: 28.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.199
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

20 review citations

Handpicking epigenetic marks with PHD fingers.
Musselman et al. (2011)
19 more

9 mentions without citation

PHD fingers: epigenetic effectors and potential drug targets.
Musselman et al. (2009)
8 more