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Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A

X-ray diffraction
3.55Å resolution
PDB entry 3c51 coloured by chain, front view.
PDB entry 3c51 coloured by chain, side view.
PDB entry 3c51 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Rhodopsin kinase GRK1
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Multimeric state: homo dimer
Accessible surface area: 47331.52 Å2
Buried surface area: 5064.14 Å2
Dissociation area: 1,232.25 Å2
Dissociation energy (ΔGdiss): -5.29 kcal/mol
Dissociation entropy (TΔSdiss): 15.18 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151206

Macromolecules

Rhodopsin kinase GRK1
Chains: A, B
Length: 543 amino acids
Theoretical weight: 61.43 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P28327 (Residues: 1-535; Coverage: 95%)
Gene names: GRK1, RHOK
Pfam:
InterPro:
CATH:
Rhodopsin kinase GRK1 in PDB entry 3c51, assembly 1, front view.
Rhodopsin kinase GRK1 in PDB entry 3c51, assembly 1, side view.
Rhodopsin kinase GRK1 in PDB entry 3c51, assembly 1, top view.
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