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Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole

X-ray diffraction
1.98Å resolution
PDB entry 3c4e coloured by chain, front view.
PDB entry 3c4e coloured by chain, side view.
PDB entry 3c4e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase pim-1
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Multimeric state: monomeric
Accessible surface area: 13122.68 Å2
Buried surface area: 242.52 Å2
Dissociation area: 121.26 Å2
Dissociation energy (ΔGdiss): -3.46 kcal/mol
Dissociation entropy (TΔSdiss): -0.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145753
Assembly 2
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Assembly Name: Serine/threonine-protein kinase pim-1
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Multimeric state: monomeric
Accessible surface area: 13123.04 Å2
Buried surface area: 242.18 Å2
Dissociation area: 121.09 Å2
Dissociation energy (ΔGdiss): -3.33 kcal/mol
Dissociation entropy (TΔSdiss): -0.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145753
Assembly 3
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Assembly Name: Serine/threonine-protein kinase pim-1
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Multimeric state: monomeric
Accessible surface area: 13030.81 Å2
Buried surface area: 245.03 Å2
Dissociation area: 122.52 Å2
Dissociation energy (ΔGdiss): -3.38 kcal/mol
Dissociation entropy (TΔSdiss): -0.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145753
Assembly 4
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Assembly Name: Serine/threonine-protein kinase pim-1
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Multimeric state: monomeric
Accessible surface area: 13083.07 Å2
Buried surface area: 242.94 Å2
Dissociation area: 121.47 Å2
Dissociation energy (ΔGdiss): -3.53 kcal/mol
Dissociation entropy (TΔSdiss): -0.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145753

Macromolecules

Serine/threonine-protein kinase pim-1
Chains: A, B, C, D
Length: 273 amino acids
Theoretical weight: 31.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 33-305; Coverage: 87%)
Gene name: PIM1
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase pim-1 in PDB entry 3c4e, assembly 1, front view.
Serine/threonine-protein kinase pim-1 in PDB entry 3c4e, assembly 1, side view.
Serine/threonine-protein kinase pim-1 in PDB entry 3c4e, assembly 1, top view.
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