› 3c1v

X-ray diffraction
1.5Å resolution

The 1.5 A Crystal structure of Ca2+-bound S100A4

Released:
DOI: 10.2210/pdb3c1v/pdb
PDB entry 3c1v coloured by chain, front view.
PDB entry 3c1v coloured by chain, side view.
PDB entry 3c1v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4.
Gingras AR, Basran J, Prescott A, Kriajevska M, Bagshaw CR, Barsukov IL
FEBS Lett 582 1651-6 (2008)
PMID: 18435928

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 113 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26447 (Residues: 1-101; Coverage: 100%)
Gene names: CAPL, MTS1, S100A4
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P32
Unit cell:
a: 52.32Å b: 52.32Å c: 139.14Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.195 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Binding of S100 proteins to RAGE: an update.
Leclerc et al. (2009)
2 more

11 mentions without citation

Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism.
Kiss et al. (2012)
10 more