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Crystal structure of catalytic domain of human histone deacetylase HDAC7

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.5.1.98: Histone deacetylase

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Systematic name:
Histone amidohydrolase
Alternative Name(s):
  • HDAC

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00850
Domain description: Histone deacetylase domain
Occurring in:
  1. Histone deacetylase 7
The deposited structure of PDB entry 3c0y contains 3 copies of Pfam domain PF00850 (Histone deacetylase domain) in Histone deacetylase 7. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000286
Domain description: Histone deacetylase family
Occurring in:
  1. Histone deacetylase 7
IPR023801
Domain description: Histone deacetylase domain
Occurring in:
  1. Histone deacetylase 7
IPR023696
Domain description: Ureohydrolase domain superfamily
Occurring in:
  1. Histone deacetylase 7
IPR037138
Domain description: Histone deacetylase domain superfamily
Occurring in:
  1. Histone deacetylase 7
IPR017320
Domain description: Histone deacetylase class II, eukaryotic-type
Occurring in:
  1. Histone deacetylase 7

Structure domain

CATH CATH domain
3.40.800.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Arginase; Chain A
Homology: Histone deacetylase domain
Occurring in:
  1. Histone deacetylase 7
The deposited structure of PDB entry 3c0y contains 3 copies of CATH domain 3.40.800.20 (Arginase; Chain A) in Histone deacetylase 7. Showing 1 copy in chain A.
SCOP SCOP annotation
52773
Class: Alpha and beta proteins (a/b)
Fold: Arginase/deacetylase
Superfamily: Arginase/deacetylase
Occurring in:
  1. Histone deacetylase 7
The deposited structure of PDB entry 3c0y contains 3 copies of SCOP domain 52773 (Histone deacetylase, HDAC) in Histone deacetylase 7. Showing 1 copy in chain A.

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