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Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

EC 2.7.11.21: Polo kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (spindle-pole-dependent)
Alternative Name(s):
  • Cdc5
  • Cdc5p
  • PLK
  • POLO kinase
  • Plk
  • Plk1
  • Plo1
  • Polo serine-threonine kinase
  • Polo-like kinase
  • Polo-like kinase 1
  • STK21
  • Serine/threonine-specific Drosophila kinase polo

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00659
Domain description: POLO box duplicated region
Occurring in:
  1. Serine/threonine-protein kinase PLK1
The deposited structure of PDB entry 3bzi contains 2 copies of Pfam domain PF00659 (POLO box duplicated region) in Serine/threonine-protein kinase PLK1. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR000959
Domain description: POLO box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR036947
Domain description: POLO box domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR033695
Domain description: Second polo-box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR033701
Domain description: First polo-box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1

Structure domain

CATH CATH domain
3.30.1120.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Arylsulfatase, C-terminal domain
Homology: POLO box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1
The deposited structure of PDB entry 3bzi contains 2 copies of CATH domain 3.30.1120.30 (Arylsulfatase, C-terminal domain) in Serine/threonine-protein kinase PLK1. Showing 2 copies in chain A.
SCOP SCOP annotation
102856
Class: Alpha and beta proteins (a+b)
Fold: Polo-box domain
Superfamily: Polo-box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1
The deposited structure of PDB entry 3bzi contains 2 copies of SCOP domain 102856 (Polo-box duplicated region) in Serine/threonine-protein kinase PLK1. Showing 2 copies in chain A.

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