PDBe 3bxk

X-ray diffraction
2.55Å resolution

Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex

Released:
Source organisms:
Entry authors: Mori MX, Vander Kooi CW, Leahy DJ, Yue DT

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP29 (Residues: 2-149; Coverage: 99%)
Gene names: CaMI, Calm, Calm1, Cam, Cam1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A Chains: B, D
Molecule details ›
Chains: B, D
Length: 21 amino acids
Theoretical weight: 2.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O00555 (Residues: 1955-1975; Coverage: 1%)
Gene names: CACH4, CACN3, CACNA1A, CACNL1A4

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 80.655Å b: 80.431Å c: 63.837Å
α: 90° β: 97.56° γ: 90°
R-values:
R R work R free
0.216 0.213 0.267
Expression systems:
  • Escherichia coli
  • Not provided