PDBe 3bwk

X-ray diffraction
2.42Å resolution

Crystal Structure of Falcipain-3 with Its inhibitor, K11017

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine protease falcipain-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 243 amino acids
Theoretical weight: 27.38 KDa
Source organism: Plasmodium falciparum
UniProt:
  • Canonical: Q9NAW4 (Residues: 250-492; Coverage: 49%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P41212
Unit cell:
a: 113.996Å b: 113.996Å c: 226.116Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.209