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Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP

X-ray diffraction
2.1Å resolution
PDB entry 3bu5 coloured by chain, front view.
PDB entry 3bu5 coloured by chain, side view.
PDB entry 3bu5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin receptor subunit beta and Insulin receptor substrate 2
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Multimeric state: hetero dimer
Accessible surface area: 14712.58 Å2
Buried surface area: 2590.54 Å2
Dissociation area: 834.06 Å2
Dissociation energy (ΔGdiss): 5.45 kcal/mol
Dissociation entropy (TΔSdiss): 8.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138935

Macromolecules

Insulin receptor subunit beta
Chain: A
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06213 (Residues: 1005-1310; Coverage: 23%)
Gene name: INSR
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Insulin receptor subunit beta in PDB entry 3bu5, assembly 1, front view.
Insulin receptor subunit beta in PDB entry 3bu5, assembly 1, side view.
Insulin receptor subunit beta in PDB entry 3bu5, assembly 1, top view.
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Insulin receptor substrate 2
Chain: B
Length: 15 amino acids
Theoretical weight: 1.72 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P81122 (Residues: 620-634; Coverage: 1%)
Gene name: Irs2
Insulin receptor substrate 2 in PDB entry 3bu5, assembly 1, front view.
Insulin receptor substrate 2 in PDB entry 3bu5, assembly 1, side view.
Insulin receptor substrate 2 in PDB entry 3bu5, assembly 1, top view.
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