PDBe 3bt1

X-ray diffraction
2.8Å resolution

Structure of urokinase receptor, urokinase and vitronectin complex

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero dimer
monomeric
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Urokinase-type plasminogen activator long chain A Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P00749 (Residues: 21-153; Coverage: 32%)
Gene name: PLAU
Sequence domains: Kringle domain
Structure domains:
Somatomedin-B Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04004 (Residues: 21-60; Coverage: 9%)
Gene name: VTN
Urokinase plasminogen activator surface receptor Chain: U
Molecule details ›
Chain: U
Length: 283 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q03405 (Residues: 23-303; Coverage: 90%)
Gene names: MO3, PLAUR, UPAR
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21212
Unit cell:
a: 97.353Å b: 105.187Å c: 55.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.241 0.308
Expression systems:
  • Drosophila melanogaster
  • Escherichia coli BL21