PDBe 3bqr

X-ray diffraction
1.75Å resolution

Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with an imidazo-pyridazine ligand

Released:
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Rellos P, Fedorov O, Niesen F, Pike ACW, Pilka ES, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death-associated protein kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 32.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43293 (Residues: 9-289; Coverage: 62%)
Gene names: DAPK3, ZIPK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 83.533Å b: 83.533Å c: 113.693Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.215
Expression system: Escherichia coli