› 3bin

X-ray diffraction
2.3Å resolution

Structure of the DAL-1 and TSLC1 (372-383) complex

Released:
DOI: 10.2210/pdb3bin/pdb
PDB entry 3bin coloured by chain, front view.
PDB entry 3bin coloured by chain, side view.
PDB entry 3bin coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).
Busam RD, Thorsell AG, Flores A, Hammarström M, Persson C, Öbrink B, Hallberg BM
J Biol Chem 286 4511-6 (2011)
PMID: 21131357

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189821 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Band 4.1-like protein 3, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 33.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2J2 (Residues: 109-390; Coverage: 26%)
Gene names: DAL1, EPB41L3, KIAA0987
Sequence domains:
Structure domains:
Cell adhesion molecule 1 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BY67 (Residues: 400-411; Coverage: 3%)
Gene names: CADM1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P65
Unit cell:
a: 135Å b: 135Å c: 50.52Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.179 0.23
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

The Protein 4.1 family: hub proteins in animals for organizing membrane proteins.
Baines et al. (2014)
2 more

5 mentions without citation

Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.
Li et al. (2017)
4 more