› 3bia

X-ray diffraction
2.2Å resolution

Tim-4 in complex with sodium potassium tartrate

Released:
DOI: 10.2210/pdb3bia/pdb
PDB entry 3bia coloured by chain, front view.
PDB entry 3bia coloured by chain, side view.
PDB entry 3bia coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds.
Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM
Immunity 27 941-51 (2007)
PMID: 18083575

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell immunoglobulin and mucin domain-containing protein 4 Chain: X
Molecule details ›
Chain: X
Length: 116 amino acids
Theoretical weight: 13.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6U7R4 (Residues: 24-134; Coverage: 35%)
Gene names: Tim4, Timd4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand TLA 1 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P6322
Unit cell:
a: 67.77Å b: 67.77Å c: 129.09Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.218 0.238
Expression system: Escherichia coli BL21

Quick links

Citations

43 review citations

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Anderson et al. (2016)
42 more