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Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)

X-ray diffraction
2.4Å resolution
PDB entry 3bhh coloured by chain, front view.
PDB entry 3bhh coloured by chain, side view.
PDB entry 3bhh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II subunit beta
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Multimeric state: monomeric
Accessible surface area: 12951.25 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171752
Assembly 2
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II subunit beta
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Multimeric state: monomeric
Accessible surface area: 12976.48 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171752
Assembly 3
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II subunit beta
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Multimeric state: monomeric
Accessible surface area: 12931.1 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171752
Assembly 4
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II subunit beta
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Multimeric state: monomeric
Accessible surface area: 13049.65 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171752

Macromolecules

Calcium/calmodulin-dependent protein kinase type II subunit beta
Chains: A, B, C, D
Length: 295 amino acids
Theoretical weight: 33.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13554 (Residues: 11-303; Coverage: 44%)
Gene names: CAM2, CAMK2, CAMK2B, CAMKB
Pfam: Protein kinase domain
InterPro:
CATH:
Calcium/calmodulin-dependent protein kinase type II subunit beta in PDB entry 3bhh, assembly 1, front view.
Calcium/calmodulin-dependent protein kinase type II subunit beta in PDB entry 3bhh, assembly 1, side view.
Calcium/calmodulin-dependent protein kinase type II subunit beta in PDB entry 3bhh, assembly 1, top view.
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