PDBe 3bhh

X-ray diffraction
2.4Å resolution

Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)

Released:
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Rellos P, Niesen F, Burgess N, Bullock A, Berridge G, Pike ACW, Ugochukwu E, Pilka ES, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 295 amino acids
Theoretical weight: 33.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13554 (Residues: 11-303; Coverage: 44%)
Gene names: CAM2, CAMK2, CAMK2B, CAMKB
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 173.4Å b: 79.2Å c: 98.7Å
α: 90° β: 104.5° γ: 90°
R-values:
R R work R free
0.225 0.223 0.275
Expression system: Escherichia coli