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Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH

Source organism: Homo sapiens
Biochemical function: mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Biological process: 7-methylguanosine mRNA capping
Cellular component: not assigned

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EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • Guanine-7-methyltransferase
  • Messenger RNA guanine 7-methyltransferase
  • Messenger ribonucleate guanine 7-methyltransferase
  • S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03291
Domain description: mRNA (guanine-N(7))-methyltransferase domain
Occurring in:
  1. mRNA cap guanine-N7 methyltransferase
The deposited structure of PDB entry 3bgv contains 4 copies of Pfam domain PF03291 (mRNA capping enzyme) in mRNA cap guanine-N7 methyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. mRNA cap guanine-N7 methyltransferase
IPR004971
Domain description: mRNA (guanine-N(7))-methyltransferase domain
Occurring in:
  1. mRNA cap guanine-N7 methyltransferase
IPR039753
Domain description: mRNA cap guanine-N7 methyltransferase
Occurring in:
  1. mRNA cap guanine-N7 methyltransferase
IPR016899
Domain description: mRNA cap guanine-N7 methyltransferase, eukaryotes
Occurring in:
  1. mRNA cap guanine-N7 methyltransferase

Structure domain

CATH CATH domain
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. mRNA cap guanine-N7 methyltransferase
The deposited structure of PDB entry 3bgv contains 4 copies of CATH domain 3.40.50.150 (Rossmann fold) in mRNA cap guanine-N7 methyltransferase. Showing 1 copy in chain B.

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