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Crystal structure of the slow form of thrombin in a self_inhibited conformation

X-ray diffraction
1.55Å resolution
PDB entry 3bei coloured by chain, front view.
PDB entry 3bei coloured by chain, side view.
PDB entry 3bei coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: alpha-thrombin complex
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Multimeric state: hetero dimer
Accessible surface area: 12983.65 Å2
Buried surface area: 3888.99 Å2
Dissociation area: 1,559.65 Å2
Dissociation energy (ΔGdiss): 14.82 kcal/mol
Dissociation entropy (TΔSdiss): 10.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133055
Complex Portal ID: CPX-6222

Macromolecules

Thrombin light chain
Chain: A
Length: 44 amino acids
Theoretical weight: 5.15 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 320-363; Coverage: 7%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
CATH: Thrombin light chain domain
Thrombin light chain in PDB entry 3bei, assembly 1, front view.
Thrombin light chain in PDB entry 3bei, assembly 1, side view.
Thrombin light chain in PDB entry 3bei, assembly 1, top view.
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Thrombin heavy chain
Chain: B
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Thrombin heavy chain in PDB entry 3bei, assembly 1, front view.
Thrombin heavy chain in PDB entry 3bei, assembly 1, side view.
Thrombin heavy chain in PDB entry 3bei, assembly 1, top view.
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