PDBe 3bea

X-ray diffraction
2.02Å resolution

cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiopoietin-1 receptor; Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 37.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02763 (Residues: 917-935; Coverage: 2%)
  • Canonical: P07333 (Residues: 538-678, 753-922; Coverage: 33%)
  • nullnull
Gene names: CSF1R, FMS, TEK, TIE2, VMCM, VMCM1
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: R3
Unit cell:
a: 81.14Å b: 81.14Å c: 145.65Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.193 0.23
Expression system: Spodoptera frugiperda