PDBe 3bbw

X-ray diffraction
4Å resolution

crystal structure of the ErbB4 kinase in its inactive conformation

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ERBB4 intracellular domain Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15303 (Residues: 702-1029; Coverage: 26%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: P61
Unit cell:
a: 102.746Å b: 102.746Å c: 181.335Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.305 0.302 0.354
Expression system: Spodoptera frugiperda