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1.6 A structure of the PCI-thrombin-heparin complex

X-ray diffraction
1.6Å resolution
PDB entry 3b9f coloured by chain, front view.
PDB entry 3b9f coloured by chain, side view.
PDB entry 3b9f coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: alpha-thrombin complex and Plasma serine protease inhibitor
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Multimeric state: hetero trimer
Accessible surface area: 27717.54 Å2
Buried surface area: 8344.02 Å2
Dissociation area: 1,676.72 Å2
Dissociation energy (ΔGdiss): 15.64 kcal/mol
Dissociation entropy (TΔSdiss): 11.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133133

Macromolecules

Thrombin light chain
Chain: L
Length: 49 amino acids
Theoretical weight: 5.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00734 (Residues: 315-363; Coverage: 8%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
CATH: Thrombin light chain domain
Thrombin light chain in PDB entry 3b9f, assembly 1, front view.
Thrombin light chain in PDB entry 3b9f, assembly 1, side view.
Thrombin light chain in PDB entry 3b9f, assembly 1, top view.
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Thrombin heavy chain
Chain: H
Length: 259 amino acids
Theoretical weight: 29.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Thrombin heavy chain in PDB entry 3b9f, assembly 1, front view.
Thrombin heavy chain in PDB entry 3b9f, assembly 1, side view.
Thrombin heavy chain in PDB entry 3b9f, assembly 1, top view.
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Plasma serine protease inhibitor
Chain: I
Length: 395 amino acids
Theoretical weight: 44.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9N2I2 (Residues: 32-404; Coverage: 96%)
Gene name: SERPINA5
Pfam: Serpin (serine protease inhibitor)
InterPro:
CATH:
Plasma serine protease inhibitor in PDB entry 3b9f, assembly 1, front view.
Plasma serine protease inhibitor in PDB entry 3b9f, assembly 1, side view.
Plasma serine protease inhibitor in PDB entry 3b9f, assembly 1, top view.
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