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Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes

X-ray diffraction
1.86Å resolution
PDB entry 3b3i coloured by chain, front view.
PDB entry 3b3i coloured by chain, side view.
PDB entry 3b3i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18703.02 Å2
Buried surface area: 6772.64 Å2
Dissociation area: 1,199.78 Å2
Dissociation energy (ΔGdiss): 8.22 kcal/mol
Dissociation entropy (TΔSdiss): 8.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135160

Macromolecules

HLA class I histocompatibility antigen, B alpha chain
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Pfam:
InterPro:
CATH:
SCOP:
HLA class I histocompatibility antigen, B alpha chain in PDB entry 3b3i, assembly 1, front view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 3b3i, assembly 1, side view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 3b3i, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 3b3i, assembly 1, front view.
Beta-2-microglobulin in PDB entry 3b3i, assembly 1, side view.
Beta-2-microglobulin in PDB entry 3b3i, assembly 1, top view.
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Vasoactive intestinal polypeptide receptor 1
Chain: C
Length: 9 amino acids
Theoretical weight: 1.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32241 (Residues: 400-408; Coverage: 2%)
Gene name: VIPR1
Vasoactive intestinal polypeptide receptor 1 in PDB entry 3b3i, assembly 1, front view.
Vasoactive intestinal polypeptide receptor 1 in PDB entry 3b3i, assembly 1, side view.
Vasoactive intestinal polypeptide receptor 1 in PDB entry 3b3i, assembly 1, top view.
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