Function and Biology

Crystal structure of the mouse HOIL1-L-NZF in complex with linear di-ubiquitin

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.3.2.31: RBR-type E3 ubiquitin transferase

Reaction catalysed:
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Systematic name:
S-ubiquitinyl-[ubiquitin-conjugating E2 enzyme]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 3b0a contains 4 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 2 copies in chain C [auth D].

InterPro InterPro annotations
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR001876
Domain description: Zinc finger, RanBP2-type
Occurring in:
  1. RanBP-type and C3HC4-type zinc finger-containing protein 1
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR036443
Domain description: Zinc finger, RanBP2-type superfamily
Occurring in:
  1. RanBP-type and C3HC4-type zinc finger-containing protein 1

Structure domains

CATH CATH domains
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 3b0a contains 4 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin. Showing 2 copies in chain C [auth D].
2.30.30.380
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Zn-finger domain of Sec23/24
Occurring in:
  1. RanBP-type and C3HC4-type zinc finger-containing protein 1
The deposited structure of PDB entry 3b0a contains 2 copies of CATH domain 2.30.30.380 (SH3 type barrels.) in RanBP-type and C3HC4-type zinc finger-containing protein 1. Showing 1 copy in chain D [auth E].