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Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.

Morishita EC, Murayama K, Kato-Murayama M, Ishizuka-Katsura Y, Tomabechi Y, Hayashi T, Terada T, Handa N, Shirouzu M, Akiyama T, Yokoyama S
Structure 19 1496-508 (2011)
Cited: 25 times
EuropePMC logo PMID: 22000517

Abstract

Adenomatous polyposis coli (APC) is a tumor suppressor protein commonly mutated in colorectal tumors. APC plays important roles in Wnt signaling and other cellular processes. Here, we present the crystal structure of the armadillo repeat (Arm) domain of APC, which facilitates the binding of APC to various proteins. APC-Arm forms a superhelix with a positively charged groove. We also determined the structure of the complex of APC-Arm with the tyrosine-rich (YY) domain of the Src-associated in mitosis, 68 kDa protein (Sam68), which regulates TCF-1 alternative splicing. Sam68-YY forms numerous interactions with the residues on the groove and is thereby fixed in a bent conformation. We assessed the effects of mutations and phosphorylation on complex formation between APC-Arm and Sam68-YY. Structural comparisons revealed different modes of ligand recognition between the Arm domains of APC and other Arm-containing proteins.

Articles - 3au3 mentioned but not cited (2)

  1. Domain architecture of BAF250a reveals the ARID and ARM-repeat domains with implication in function and assembly of the BAF remodeling complex. Sandhya S, Maulik A, Giri M, Singh M. PLoS ONE 13 e0205267 (2018)
  2. The structural biology of canonical Wnt signalling. Agostino M, Pohl SÖ. Biochem Soc Trans 48 1765-1780 (2020)


Reviews citing this publication (6)

  1. Can we safely target the WNT pathway? Kahn M. Nat Rev Drug Discov 13 513-532 (2014)
  2. Role of Sam68 in post-transcriptional gene regulation. Sánchez-Jiménez F, Sánchez-Margalet V. Int J Mol Sci 14 23402-23419 (2013)
  3. Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2). Mills RD, Mulhern TD, Liu F, Culvenor JG, Cheng HC. Hum. Mutat. 35 395-412 (2014)
  4. Targeting the Wnt Pathway in Cancer: A Review of Novel Therapeutics. Tabatabai R, Linhares Y, Bolos D, Mita M, Mita A. Target Oncol 12 623-641 (2017)
  5. Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy. Yang X, Zhong J, Zhang Q, Feng L, Zheng Z, Zhang J, Lu S. Front Mol Biosci 8 662579 (2021)
  6. Shifting the Focus of Signaling Abnormalities in Colon Cancer. Brown MA, Ried T. Cancers (Basel) 14 784 (2022)

Articles citing this publication (17)

  1. Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations. Minde DP, Radli M, Forneris F, Maurice MM, Rüdiger SG. PLoS ONE 8 e77257 (2013)
  2. Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex. Kunttas-Tatli E, Roberts DM, McCartney BM. Mol. Biol. Cell 25 3424-3436 (2014)
  3. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J, Zhang J. Nat. Chem. Biol. 13 994-1001 (2017)
  4. Intrinsically disordered proteins in the nucleus of human cells. Frege T, Uversky VN. Biochem Biophys Rep 1 33-51 (2015)
  5. Nuclear Magnetic Resonance Structure of a Novel Globular Domain in RBM10 Containing OCRE, the Octamer Repeat Sequence Motif. Martin BT, Serrano P, Geralt M, Wüthrich K. Structure 24 158-164 (2016)
  6. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners. Zhang Z, Akyildiz S, Xiao Y, Gai Z, An Y, Behrens J, Wu G. Cell Discov 1 15016 (2015)
  7. Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling. Lee HK, Lee EW, Seo J, Jeong M, Lee SH, Kim SY, Jho EH, Choi CH, Chung JY, Song J. Oncogene 37 4273-4286 (2018)
  8. Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. Luan Q, Liu SL, Helgeson LA, Nolen BJ. EMBO J. 37 (2018)
  9. The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells. Yedid N, Kalma Y, Malcov M, Amit A, Kariv R, Caspi M, Rosin-Arbesfeld R, Ben-Yosef D. BMC Cancer 16 952 (2016)
  10. The structure of TON1937 from archaeon Thermococcus onnurineus NA1 reveals a eukaryotic HEAT-like architecture. Jeong JH, Kim YS, Rojviriya C, Cha HJ, Ha SC, Kim YG. Int. J. Biol. Macromol. 61 433-438 (2013)
  11. APC Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome. Disciglio V, Forte G, Fasano C, Sanese P, Lepore Signorile M, De Marco K, Grossi V, Cariola F, Simone C. Genes (Basel) 12 353 (2021)
  12. Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin. Holzer S, Degliesposti G, Kilkenny ML, Maslen SL, Matak-Vinkovíc D, Skehel M, Pellegrini L. Nucleic Acids Res. 45 5555-5563 (2017)
  13. Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors. Al-Thani NM, Schaefer-Ramadan S, Aleksic J, Mohamoud YA, Malek JA. Cancer Cell Int 22 376 (2022)
  14. Molecular Docking and Site-Directed Mutagenesis of GH49 Family Dextranase for the Preparation of High-Degree Polymerization Isomaltooligosaccharide. Wang H, Lin Q, Liu M, Ding W, Weng N, Ni H, Lu J, Lyu M, Wang S. Biomolecules 13 300 (2023)
  15. Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocles. Lai KKY, Kahn M. Handb Exp Pharmacol 269 383-422 (2021)
  16. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing. Subramania S, Gagné LM, Campagne S, Fort V, O'Sullivan J, Mocaer K, Feldmüller M, Masson JY, Allain FHT, Hussein SM, Huot MÉ. Nucleic Acids Res. 47 4181-4197 (2019)
  17. Two-Dimensional Polyacrylamide Gel Electrophoresis Coupled with Nanoliquid Chromatography-Tandem Mass Spectrometry-Based Identification of Differentially Expressed Proteins and Tumorigenic Pathways in the MCF7 Breast Cancer Cell Line Transfected for Jumping Translocation Breakpoint Protein Overexpression. Jayathirtha M, Jayaweera T, Whitham D, Petre BA, Neagu AN, Darie CC. Int J Mol Sci 24 14714 (2023)


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