PDBe 3apd

X-ray diffraction
2.55Å resolution

Crystal structure of human PI3K-gamma in complex with CH5108134

Released:

Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Chain: A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 142.95Å b: 67.46Å c: 106.28Å
α: 90° β: 95.68° γ: 90°
R-values:
R R work R free
0.253 0.25 0.316
Expression system: Spodoptera frugiperda