PDBe 3ad4

X-ray diffraction
2.2Å resolution

Crystal Structure of Methoxy Benzofuran Derivative bound to the Kinase domain of human LCK, (auto-phosphorylated on TYR394)

Source organism: Homo sapiens
Entry author: Tsuji E

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P06239 (Residues: 225-509; Coverage: 56%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P212121
Unit cell:
a: 42.277Å b: 73.612Å c: 92.76Å
α: 90° β: 90° γ: 90°
R R work R free
0.177 0.169 0.256
Expression system: Spodoptera frugiperda