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Crystal structure of human COMT complexed with SAM and 3,5-dinitrocatechol

Source organism: Homo sapiens
Biochemical function: catechol O-methyltransferase activity
Biological process: catecholamine metabolic process
Cellular component: not assigned

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EC 2.1.1.6: Catechol O-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
Systematic name:
S-adenosyl-L-methionine:catechol O-methyltransferase
Alternative Name(s):
  • COMT I
  • COMT II
  • Catechol methyltransferase
  • Catecholamine O-methyltransferase
  • MB-COMT (membrane-bound form of catechol-O-methyltransferase)
  • S-COMT (soluble form of catechol-O-methyltransferase)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01596
Domain description: O-methyltransferase
Occurring in:
  1. Catechol O-methyltransferase
The deposited structure of PDB entry 3a7e contains 1 copy of Pfam domain PF01596 (O-methyltransferase) in Catechol O-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Catechol O-methyltransferase
IPR002935
Domain description: Class I-like SAM-dependent O-methyltransferase
Occurring in:
  1. Catechol O-methyltransferase
IPR017128
Domain description: Catechol O-methyltransferase, eukaryotic
Occurring in:
  1. Catechol O-methyltransferase

Structure domain

CATH CATH domain
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. Catechol O-methyltransferase
The deposited structure of PDB entry 3a7e contains 1 copy of CATH domain 3.40.50.150 (Rossmann fold) in Catechol O-methyltransferase. Showing 1 copy in chain A.

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