PDBe 3a60

X-ray diffraction
2.8Å resolution

Crystal structure of unphosphorylated p70S6K1 (Form I)


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Ribosomal protein S6 kinase beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 36.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P23443 (Residues: 75-399; Coverage: 62%)
Gene names: RPS6KB1, STK14A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 78.6Å b: 62.893Å c: 86.992Å
α: 90° β: 94.32° γ: 90°
R R work R free
0.21 0.21 0.268
Expression system: Spodoptera frugiperda