PDBe 3a4p

X-ray diffraction
2.54Å resolution

human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors.
Bioorg. Med. Chem. Lett. 20 1405-9 (2010)
PMID: 20093027

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 319 amino acids
Theoretical weight: 35.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08581 (Residues: 1049-1360; Coverage: 23%)
Gene name: MET
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2
Unit cell:
a: 157.227Å b: 42.733Å c: 46.039Å
α: 90° β: 102.91° γ: 90°
R-values:
R R work R free
0.186 0.183 0.24
Expression system: Spodoptera frugiperda