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Lyn kinase domain

X-ray diffraction
3Å resolution
PDB entry 3a4o coloured by chain, front view.
PDB entry 3a4o coloured by chain, side view.
PDB entry 3a4o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Lyn
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Multimeric state: monomeric
Accessible surface area: 12313.6 Å2
Buried surface area: 830.28 Å2
Dissociation area: 415.14 Å2
Dissociation energy (ΔGdiss): -1.94 kcal/mol
Dissociation entropy (TΔSdiss): 4.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139851

Macromolecules

Tyrosine-protein kinase Lyn
Chain: X
Length: 286 amino acids
Theoretical weight: 32.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07948 (Residues: 233-512; Coverage: 55%)
Gene names: JTK8, LYN
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase Lyn in PDB entry 3a4o, assembly 1, front view.
Tyrosine-protein kinase Lyn in PDB entry 3a4o, assembly 1, side view.
Tyrosine-protein kinase Lyn in PDB entry 3a4o, assembly 1, top view.
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