Function and Biology Details
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Proliferating cell nuclear antigen, PCNA
- DNA-directed DNA polymerase, family B
- DNA clamp superfamily
- DNA-directed DNA polymerase, family B, exonuclease domain
- Proliferating cell nuclear antigen, PCNA, C-terminal
- Proliferating cell nuclear antigen, PCNA, conserved site
- Proliferating cell nuclear antigen, PCNA, N-terminal
- DNA polymerase family B, thumb domain
6 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
DNA polymerase sliding clamp and DNA polymerase (preferred)
PDBe Complex ID:
PDB-CPX-130734 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA polymerase
Molecule details ›
Chain: A
Length: 775 amino acids
Theoretical weight: 90.72 KDa
Source organism: Pyrococcus furiosus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 775 amino acids
Theoretical weight: 90.72 KDa
Source organism: Pyrococcus furiosus
Expression system: Escherichia coli
UniProt:
- Canonical:
P61875 (Residues: 1-775; Coverage: 100%)
Sequence domains:
Structure domains:
DNA polymerase sliding clamp
Molecule details ›
Chain: B
Length: 248 amino acids
Theoretical weight: 28.17 KDa
Source organism: Pyrococcus furiosus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 248 amino acids
Theoretical weight: 28.17 KDa
Source organism: Pyrococcus furiosus
Expression system: Escherichia coli
UniProt:
- Canonical: O73947 (Residues: 2-249; Coverage: 100%)
Sequence domains:
- Proliferating cell nuclear antigen, N-terminal domain
- Proliferating cell nuclear antigen, C-terminal domain
