PDBe 3zhp

X-ray diffraction
2.9Å resolution

Human MST3 (STK24) in complex with MO25beta

Released:
Source organism: Homo sapiens
Primary publication:
Structural insights into the activation of MST3 by MO25.
OpenAccess logo Biochem. Biophys. Res. Commun. 431 604-9 (2013)
PMID: 23296203

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calcium-binding protein 39-like Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 39.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H9S4 (Residues: 5-337; Coverage: 99%)
Gene name: CAB39L
Sequence domains: Mo25-like
Structure domains: Leucine-rich Repeat Variant
Serine/threonine-protein kinase 24 36 kDa subunit Chains: C, D
Molecule details ›
Chains: C, D
Length: 294 amino acids
Theoretical weight: 33.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6E0 (Residues: 31-301; Coverage: 61%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 64.8Å b: 120.34Å c: 98.91Å
α: 90° β: 99.69° γ: 90°
R-values:
R R work R free
0.228 0.227 0.261
Expression system: Escherichia coli BL21(DE3)