PDBe 3zgo

X-ray diffraction
1.63Å resolution

Re-refined structure of the human Sirt2 apoform

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 325 amino acids
Theoretical weight: 36.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IXJ6 (Residues: 34-356; Coverage: 83%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: null, CHESS BEAMLINE F1
Spacegroup: C2221
Unit cell:
a: 78.94Å b: 119.07Å c: 218.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.168 0.195
Expression system: Escherichia coli BL21(DE3)