PDBe 3zew

X-ray diffraction
2.5Å resolution

Crystal structure of EphB4 in complex with staurosporine


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Ephrin type-B receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 33.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P54760 (Residues: 598-892; Coverage: 30%)
Gene names: EPHB4, HTK, MYK1, TYRO11
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 52.17Å b: 88.71Å c: 80.78Å
α: 90° β: 103.05° γ: 90°
R R work R free
0.24 0.238 0.282
Expression system: Escherichia coli BL21(DE3)