PDBe 3wpt

X-ray diffraction
2.63Å resolution

Crystal structure of closed dimer of human importin-alpha1 (Rch1)

Released:
Source organism: Homo sapiens
Entry authors: Miyatake H, Sanjoh A, Matsuda G, Tatsumi Y, Dohmae N, Aida Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin subunit alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 423 amino acids
Theoretical weight: 45.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52292 (Residues: 75-497; Coverage: 80%)
Gene names: KPNA2, RCH1, SRP1
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P43212
Unit cell:
a: 139.299Å b: 139.299Å c: 141.288Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.216
Expression system: Escherichia coli