PDBe 3wlw

X-ray diffraction
3.09Å resolution

Molecular Architecture of the ErbB2 Extracellular Domain Homodimer

Released:
Source organism: Homo sapiens
Primary publication:
Molecular architecture of the ErbB2 extracellular domain homodimer.
OpenAccess logo Oncotarget 6 1695-706 (2015)
PMID: 25633808

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody H Chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 217 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Antibody L Chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 217 amino acids
Theoretical weight: 23.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Receptor tyrosine-protein kinase erbB-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 564 amino acids
Theoretical weight: 62.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P04626 (Residues: 23-586; Coverage: 46%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P1
Unit cell:
a: 84.716Å b: 104.185Å c: 116.712Å
α: 106.89° β: 99.65° γ: 111.12°
R-values:
R R work R free
0.234 0.232 0.269
Expression system: Cricetulus griseus