PDBe 3w81

X-ray diffraction
2.3Å resolution

Human alpha-l-iduronidase

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-L-iduronidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 627 amino acids
Theoretical weight: 70.12 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: NEW P35475 (Residues: 27-653; Coverage: 100%)
Gene name: IDUA
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A, PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: R3
Unit cell:
a: 259.225Å b: 259.225Å c: 71.835Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.169 0.21
Expression system: Cricetulus griseus