PDBe 3w0t

X-ray diffraction
1.35Å resolution

Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Fukami TA, Irie M, Matsuura T

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoylglutathione lyase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 187 amino acids
Theoretical weight: 21.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04760 (Residues: 1-184; Coverage: 100%)
Gene name: GLO1
Sequence domains: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Structure domains: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: P21
Unit cell:
a: 66.57Å b: 81.03Å c: 68.62Å
α: 90° β: 90.13° γ: 90°
R-values:
R R work R free
0.176 0.175 0.197
Expression system: Escherichia coli