PDBe 3vhk

X-ray diffraction
2.49Å resolution

Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 41.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35968 (Residues: 806-1171; Coverage: 27%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: C2
Unit cell:
a: 135.719Å b: 56.354Å c: 51.875Å
α: 90° β: 95.61° γ: 90°
R-values:
R R work R free
0.21 0.207 0.262
Expression system: Spodoptera frugiperda