PDBe 3vhe

X-ray diffraction
1.55Å resolution

Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor.


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 359 amino acids
Theoretical weight: 40.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P35968 (Residues: 811-1169; Coverage: 27%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: C2
Unit cell:
a: 134.34Å b: 56.27Å c: 52.07Å
α: 90° β: 95.24° γ: 90°
R R work R free
0.186 0.186 0.209
Expression system: Spodoptera frugiperda